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What Is the Prognosis of Alport Syndrome


2012-09-28 18:25

Alport syndrome is a genetic disease featured with sarring of filtering units called glomeruli in kidneys. Its prognosis varies with the prognosis of alport syndrome.

Alport syndrome can gradual loss of renal function through the replacement of normal kidney structures by scar tissue. Generally speaking, women with this condition only have slight hearing lose and most of them can lead a normal life. However, men are usually associated with a poor prognosis.

Most of men with X-linked alport syndrome will experience kidney failure in their 20s or 30s, which eventually require dialysis or kidney transplant. However, kidney failure may be delayed until 40~50 years of age in some men with alport syndrome. Also many men develop significant hearing loss and they may die of complications by middle age. Most of women with X-linked alport syndrome will not develop kidney failure. However, the risk of developing renal failure increases as they age.

All men and women with recessive alport syndrome develop renal failure, usually by age 20s~30s. People with autosomal alport syndrome usually develop renal failure by their middle age.

Additionally, proteinuria and high blood pressure is associated with prognosis of alport syndrome closely. If the amount of protein in urine is above 1 g/d, it indicates a poor prognosis. Therefore, to reduce proteinuria, it is important for the patients to limit the intake of foods loaded in proteins. High blood pressure can put extra workload on the tiny blood vessels in kidneys and it can make them worn out. The patients are usually recommended to reduce high blood pressure to less than 130/80 mmHg, which will improve the prognosis.

At present, while there is no cure for alport syndrome, an effective treatment can slow down its progression and improve its prognosis significantly.


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