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Routine Alport Syndrome Treatment

2012-09-21 11:05

Routine Alport Syndrome TreatmentAlport Syndrome is a genetic disorder. Presently, there is no a cure for genetic disease. The routine treatment is designed to controlling complications of the disease and slow down its progression.

Control blood pressure and proteinuria

Controlling high blood pressure can reduce the risk of renal function deterioration in Alport Syndrome remarkably.Angiotensin-converting enzyme(ACE) inhibitors and angiotensin receptor blockers (ARBs) are commonly prescribed to the patients with Alport Syndrome. They are not only can reduce blood pressure, but also can reduce proteinuria and delay progression to renal failure. These medications should be given to patients with Alport Syndrome who have proteinuria with or without high blood pressure.

However, ACE inhibitors may cause some complications.Cough, elevated blood potassium levels, low blood pressure, headache, weakness and rash are commonly seen. In rare cases, kidney failure, a decrease in white blood cells and angioedema can be seen in patients on ACE inhibitors.

Monitoring regularly

Along with control of high blood pressure and proteinuria, Alport Syndrome patients should be monitored regularly. 24-hour urinary protein, creatinine, and serum chemistry should be monitored regularly.

As Alport Syndrome can involve hearing and vision, they should also be monitored every one to two years.

Avoid nephrotoxic drugs

The patients with Alport Syndrome should avoid nephrotoxic drugs and harmful substances to kidneys. This kind of medications mainly include non-steroidal anti-inflammatory drugs like aspirin, ibuprofen and naproxen. When seeing a doctor, the patients should tell their doctors about their kidney disease and get guidance on medicines that should be avoided.

Renal replacement therapy

When Alport Syndrome progresses into end stage renal disease, the routine treatment options of the patients include dialysis and kidney transplant. As Alport Syndrome is a genetic disorder, related kidney donors must be carefully evaluated for this disease

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