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Diagnosis of Chronic Allograft Nephropathy: Immune Special Tests

Provided by Expert Zhang Youkang on 2012-10-27 11:31

Chronic Allograft Nephropathy is one of the major causes of late graft loss in Kidney Transplant recipients. CAN is highly prevalent in renal transplant recipients, with moderate to severe CAN present in 24.7% of one year post-transplant recipients and in 89.8% by 10 years post transplant. Here, we will introduce the diagnosis of Chronic Allograft Nephropathy by immune special tests as below.

▪ Kidney Damage Tests

Aims: 1) confirm the kidney damage; 2) the damaged part, glomerulus or renal tubules; 3) make the severity of kidney damage clear and guide the clinical choice of medicine; 4) judge patient's sensitivity to medicines and guide the clinical medicine application.

Checking items include: UTP, U-malb, U-TRF, U-IGG, β 2-microglobulin, α1-microglobulin, α2-macroglobulin, κ light chain, λ light chain, U- NAG, U-GGT, and Uosm.

▪ Toxins in Blood Tests

Aims: 1) Make the buildup of toxins in the body clear; 2) guide the choice of immune clearance method.

Checking items include: BUN, Creatinine, UA, β 2-microglobulin, Cyc C, RBP, HCY, and PTH.

▪ Urinary Protein Electrophoresis

This test is used to analysis the composition of urine protein. Aims: 1) judge the source of proteinuria; 2) make differential diagnosis of various kidney diseases; 3) determine patient's drug susceptibility.

This is a general introduction of immune special diagnosis of Chronic Allograft Nephropathy. On the basis of an accurate diagnosis of each patient's condition, we can adopt the most suitable treatment so as to ensure the most satisfactory curative effects. In China, we apply Immunotherapy for this disease. Here is some information for your reference (Alternative Treatment for Failed Kidney Transplant except Dialysis).

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