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Elevated Creatinine Level in Chronic Allograft Nephropathy

Provided by Expert Zhang Youkang on 2013-02-06 16:44

Chronic Allograft Nephropathy (CAN) is the leading cause of kidney transplant failure and occurs moth to years after the transplant. When it occurs, the renal function will decline gradually. As a result, elevated creatinine level will occur. What are the risk factors of chronic allograft nephropathy?

Donor age

Donor age explains approximately 30% of the variance in graft outcome beyond one year. A relative deficiency in the number of nephrons vis-a-visa the recipient’s metabolic demands.

Prolonged ischemic exposure

After Kidney Transplant, if the new kidney stays in ischemic state for too long, it also cause inferior long-term outcome.

Acute rejection episodes

Acute rejection is a significant cause of failure of kidney transplant. It can cause the new kidney to failure in several days.

Chronic rejection

Kidney rejection episodes that occur months or years after kidney transplant are at a high risk of evolving into chronic allograft nephropathy.

Elevated cholesterol levels

Hypertriglyceridemia is an independent risk factor of late graft loss.

High blood pressure

Recipient hypertension protends a poorer outcome with a faster decline in function and a grater likelihood of return to dialysis compared with patients with a normal blood pressure.

The above are risk factors of chronic allograft nephropathy. Once the new kidney loses its normal function, creatinine and other metabolic wastes will build up in body, leading to elevated creatinine.

To lower elevated creatinine in chronic allograft nephropathy, firstly it is important to eliminate the causes of failure of the new kidney. It can help stop the further damage to kidney.

Elevated creatinine level indicates that about 50% of your renal function has been lost. If left uncontrolled, new kidney transplant will have to be performed soon. To lower elevated creatinine level in chronic allograft nephropathy, the key treatment step is to restore impaired kidney structure and improve renal function. If the renal function can be improved, another Kidney Transplant will not be necessary.

For more information on chronic allograft nephropathy, please consult us on line.

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