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Treatment of Chronic Allograft Nephropathy in Western Medicine I


2012-09-17 08:36

Chronic Allograft Nephropathy (CAN) is a common cause of Kidney Failure following transplant surgery, characterized by slowly progressive graft dysfunction ultimately leading to Chronic Renal Failure. Western medicine involves many treatments for CAN. Here are detailed introduction.

* Adjustment of immunosuppressive drugs.

Through analysing and determining the specific cause of CAN as well as evaluating a variety of influencing factors, proper immunosuppressive medicine treatment plan can be made. For instance, in case of insufficient immune inhibition, more effective medications can be used or properly improve the density of medicine.

* Application of ACEI or Angiotensin II receptor blocker.

TGF-β1, a critical factor of fibrosis process, may play an important role in the occurrence of CAN. Its production is regulated by renin-angiotensin system (RAS). This system induces the production of glomerular mesangial cells and secretion of TGF-β1. The application of CEI or Angiotensin II receptor blocker can obviously reduce the serum TGF-β1 level. In this way, both of the high blood pressure and protein in urine can be effectively lowered.

* Restrict the intake of protein in diet.

Long-term high protein diet can lead to persistent glomerular filtration and eventually glomerulosclerosis. A low-protein diet can reduce the production of metabolism substance so as to relieve the pressure on residual nephrons and reduce glomerular damage, thus delaying the eventual Kidney Failure. Besides, in order to avoid malnutrition, essential amino acid should be given to supplement vitamins.

The above is just part of introduction, continue reading "Treatment of Chronic Allograft Nephropathy in Western Medicine II" to get more information.




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