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Can High Uric Acid Cause Decreased Kidney Function


2013-11-13 13:38

Can High Uric Acid Cause Decreased Kidney FunctionUric acid is the terminal metabolites of purine compounds. When too much uric acid is produced or the kidneys fail to excrete a sufficient amount of uric acid, a buildup can occur, resulting in high uric acid. Can high uric acid cause decreased kidney function? The answer is yes.

How high uric acid causes decreased kidney function?

Kidneys remove water, wastes, and electrolytes from the body. 30 percent of uric acid is discharged by intestinal and biliary tract. While about 70 percent of uric acid is discharged by kidney. If it is not excreted timely, too much uric acid in the blood crystallize easily. When uric acid crystal deposits on kidney, it will lead to inflammation of renal arteriole and chronic interstitial. With the worsening of inflammation, kidney function gradually loses and if left alone, it eventually causes chronic kidney disease and even kidney failure. Recently, uric acid is seen as a potential contributory risk factor in the development and progression of CKD. And most studies documented that an elevated serum uric acid level independently predicts the development of CKD.

What should we do to prevent excess uric acid in daily?

-Drink enough water.

-Stop excessive alcohol intake.

-Limit the consumption of food high in purines such as asparagus, mushrooms and organ meat.

-Get rid of indulgence in a serious exercise program and do mild exercise.

-Limit the consumption of caffeine.

-Avoid lead poisoning.

-Control your weight.

Medications for high uric acid

-Medicines which increase the drainage of uric acid, such as benzbromarone, probenecid, Sulfinpyrazone etc.

-Medicines which decrease the uric acid, such as losartan, fenofibrate.

You should take medicine under the instruction of doctors, do not use diuretic at random., such as thiazides, corticosteroids, ciclosporin and so on. Though they are helpful for urination, they can also increase uric acid in the blood.

High uric acid can lead to kidney disease, so we must pay attention in case of aggravating our condition. If you still have other questions, you can leave us a message or email to kidneyabc@hotmail.com, and we will make a personalized treatment according to your illness.




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