Glomerular filtration rate (GFR) is used to measure how well your kidneys are functioning. It estimates how much blood passes through glomeruli in each minute.
Normal GFR ranges from 90~120 ml/min/1.73 m2. Older people will have lower normal GFR levels, because GFR decreases with age. Levels below 60 ml/min/1.73 m2 for 3 months or more than months are a sign of chronic kidney disease( CKD). Therefore, GFR 51 does not necessarily indicate kidney disease. Reduced GFR is mainly due to the following factors:
Angiotensin converting enzyme (ACE) inhibitors and the nonsteroidal anti-inflammatory drugs (NSAIDs) are two kinds of common drugs. These medications have the potential to substantially alter kidney perfusion. If less blood is supplied to kidneys, GFR will decline. Reduced GFR can cause a rise in serum creatinine.
Other medications may require serum monitoring mainly including antibiotics and antiarrhythmics.
* Low blood pressure
Kidney can maintain certain renal blood flow to maintain blood pressure at 130/80 mmHg. When blood pressure declines, the renal perfusion will decline, thus resulting in reduced GFR. Therefore, the most important element in maintaining optimal kidney perfusion is the avoidance of hypotension and the maintenance of adequate hydration.
Dehydration is a common cause of reduced GFR which is caused by decreased fluid intake, decreased thirst, diuretics and diarrhea, etc. This condition can reduce the total blood volume in body, thus reducing renal perfusion.
CKD is the leading cause of reduced GFR. As the kidneys are damaged, less blood will pass through kidneys. Thereby, reduced GFR will occur.
The above are common causes of reduced GFR. If you are suffering from the condition, you should find out the causes and then take the relative measures to control it.