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Risk Factors of Chronic Kidney Disease in Children

2012-10-27 17:03

In early stage of children chronic kidney disease, the patients experience no symptom at all. The major risk factors for chronic kidney disease in children mainly include:

Cardiovascular disease

Cardiovascular disease is a major death cause in both children and adults with chronic kidney disease. It is mainly due to the following causes:

* Heart overload

As kidneys are damaged, excessive fluids will build up in body, thus leading to increased blood volume. High blood pressure and increased blood volume can cause heart overload.

Moreover, in children chronic kidney disease, atherosclerosis and high blood pressure occur commonly. These conditions can damage blood vessels. Especially, if phosphorus level is too high in blood, it can cause angiosteosis. Hyperphosphatemia can increase the mortality of children with chronic kidney disease significantly.


Proteinuria can reflect the prognosis of children chronic kidney disease. Even if renal function keeps normal, heavy proteinuria indicates progressive kidney damage. Therefore, it is very important to control proteinuria as early as possible. ACE inhibitor is effective in reducing proteinuria. Some studies show that if proteinuria reduces to less than 2ml/min, the decline rate of GFR will reduce to less than 2 ml/min. Therefore, it is very important to control proteinuria.


Dyslipidemia is an independent factor of renal function deterioration and also can increase the risk of cardiovascular diseases.


Anemia is an important risk factor of chronic kidney disease. When anemia occurs, hyoxemia can damage kidney tissues and production of extracellular matrix, thus worsening renal function. EPO can improve anemia and improve oxygen to kidneys.


Some genetic factors are also associated with the progression of chronic kidney disease in children. Additionally, obesity and unhealthy habits like smoking can increase the risk of chronic kidney disease progression.

The above are the major risk factors of children chronic kidney disease. If those factors are avoided, it will slow down the disease progression and improv the disease prognosis effectively.

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