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Indicators Are Related To Kidney Functions In Clinic

2018-09-19 09:22

Kidney Functions,IndicatorsWhen glomerular filtration function is impaired due to the Kidney Disease, the renal reserve and compensatory power is still very strong, so in the early or mild damage, serum creatinine concentration can be normal, only when the glomerular filtration function drops to 1/3 of the normal people, serum creatinine value increased significantly.

Blood pressure (BP):

Mild hypertension is one of the main causes of hypertensive kidney disease. Severe long-term hypertension can damage the arteries, leading to heart failure, brain edema and even cerebral hemorrhage. Many antihypertensive drugs are effective in treating hypertension. Low salt diet is effective for more than 10% hypertensive patients. Hypertension caused by overweight should be treated with weight loss. Sympathetic nerve transection in hypertensive patients with ineffective drug treatment is effective for about 10% of patients.

Serum creatinine (Scr):

Clinical detection of serum creatinine is one of the main methods to understand renal function. What about creatinine? Creatinine is the product of human muscle metabolism. In muscle, creatinine is slowly formed by irreversible non-enzymatic dehydration and then released into the blood and excreted in urine. Therefore, serum creatinine is closely related to the total amount of muscle in the body, and is not easy to be influenced by diet. Creatinine is a small molecule substance that can be filtered through the glomerulus. It is seldom absorbed in the renal tubules. The creatinine produced in the body every day is almost completely excreted with the urine and is generally not affected by the amount of urine. When renal insufficiency occurs, the accumulation of creatinine in the body becomes a harmful toxin to human body. The normal upper limit of plasma creatinine is 100 micromolar / litre.

Normal serum or plasma creatinine levels were 53-106 mmol/L in males and 44-97 mmol/L in females.

Creatinine detection increased mainly in acute or chronic glomerulonephritis and other kidney diseases. When glomerular filtration function is impaired due to the above-mentioned diseases, the renal reserve and compensatory power is still very strong, so in the early or mild damage, serum creatinine concentration can be normal, only when the glomerular filtration function drops to 1/3 of the normal people, the serum creatinine value increases significantly.

The simultaneous determination of serum creatinine and urea nitrogen is more meaningful, if both increase simultaneously, indicating that renal function has been seriously damaged.

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