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Will All People with Diabetes Develop Diabetic Nephropathy

2012-10-30 18:42

If diabetes is not controlled well, it may lead to kidney damage and accumulation of extracellular matrix in glomeruli. Eventually, glomerulosclerosis will occur. However, not all people with diabetes will develop diabetic nephropathy.

Whether diabetes will develop into diabetic nephropathy is related to genetics as well as treatment they receive and control of blood sugar. Diabetes is the leading cause of renal failure in western countries. Thereby, it is very important for people with diabetic nephropathy to take treatment as early as possible.

In early stages of diabetic nephropathy, if early intervention treatment is adopted, the condition can be reversed completely. Generally speaking, if the patients can take treatment in stage 1 of diabetic nephropathy, the kidney damage can be reversed completely. In stages of 2 and 3, the glomerular basilar membrane becomes thick and mesangial matrix widens. As the kidneys have changes in structure, proper treatment can delay the disease progression significantly. Therefore, it is very important for the patients with diabetes to do GFR test regularly and UAER.

However, many patients with diabetes do not pay much attention to early inspection and treatment of kidney damage. Many of them do not go to see a doctor until proteinuria and swelling appear. If so, the disease has at least developed into stage 4. What’s worse, once heavy proteinuria occurs, renal function will aggravate rapidly. The patients may develop end stage renal failure within five years. Therefore, it is very important for the patients with diabetic nephropathy to treat proteins in urine effectively.

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