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Diabetic Nephropathy

Diabetic Nephropathy basics


Diabetic Nephropathy is secondary disease of Diabetes. It is leading cause of Renal Failure worldwide. But not all with Diabetes will develop kidney damage.


In right condition, the blood vessels in kidneys help filter wastes from blood. However, in Diabetes, if blood sugar level is not controlled well, high blood sugar can destroy these blood vessels. Over time, the kidneys will lose the ability to filter blood gradually. Later it may stop working completely and develop into Renal Failure.

The statistics show that 40% people with Diabetes will develop kidney damage. The risk factors for developing Diabetic Nephropathy mainly include high blood pressure or high cholesterol,or if you smoke or drink. Also, is is related to races.


In the early stage of Diabetic Nephropathy, the patients usually do not have symptoms. But a small amount of protein may be found in urine. If the patients can find kidney damage as early as possible, sometimes the kidney damage can be reversed.

However, if the disease is not controlled or controlled improperly, a myriad of symptoms will appear as the disease progresses.

* High blood pressure

It can accelerate the deterioration of renal function.

* Increased cholesterol and triglyceride

It can increase the risk of cardiovascular diseases and heart disease significantly.

* Foamy appearance of urine

It is due to protein loss in urine and also can accelerate renal function decline.

* Swelling

As kidneys are less able to do their job, a large amount of fluids will build up in body, leading to swelling.


* Keep blood sugar in target range

* Control blood pressure at a target of less than 130/80 mmHg.

* Stay at a healthy weight, exercise regularly and eat a low-fat diet.

* Watch how much proteins to eat. Eating too much protein can put much strain on kidneys. Limiting how much protein you can eat may help to preserve kidney function.

* Limiting salt intake can keep high blood pressure from getting worse.

* Quit smoking and drinking.

If you have been diagnosed with Diabetic Nephropathy, we're here to help. Call us: +86-311-89261580 OR Viber/Whatsapp: +86 13503211882 or email us: through Sunday) to make an appointment.

Diabetic Nephropathy symptoms

Diabetic Nephropathy is secondary to Diabetes. In people with Type 1 Diabetes, Diabetic Nephropathy usually develops 5~10 years after the onset of Diabetes. As Type 2 Diabetes often develop asymptomatically for several years, people may find out kidney damage at the first diagnosis of Diabetes.

In the early stages of Diabetic Nephropathy, the patients usually do not present obvious clinical symptoms. The only sign of kidney damage may be small amounts of protein in urine. Normally, proteinuria does not occur except during some stress states, such as high fever, strenuous exercise, infection, trauma, or surgery.

As Diabetic Nephropathy progresses, your kidneys are unable to work adequately to filter blood and get rid of toxins and wastes from body. And they fail to balance the chemicals in your blood very well. You may experience the following symptoms and signs:

* Increased protein loss in urine.

As the disease progresses, the filtering system in is damaged further. More proteins pass through glomeruli and end up in urine.

* Higher blood pressure

Higher blood pressure is mainly attributable to increased retention of fluids and sodium in body.

* Higher cholesterol levels

Increased cholesterol levels are due to protein loss from blood. This problem can increase the risk of cardiovascular diseases and heart failure.

If uncontrolled or treated improperly, your Diabetic Nephropathy will get worse. These symptoms include:

* Swelling

Swelling firstly occurs in the feet and legs and later spread throughout your body. It is mainly attributable to retention of fluids and sodium in body.

* Poor appetite

The kidneys fail to filter out urea nitrogen from body, thus leading to building up in blood. The urea nitrogen can be decomposed into ammonia with the help of urease. Ammonia can irritate gastrointestinal mucosa, leading to nausea, vomiting and poor appetite.

* Weight loss

As the patients have to limit the intake of proteins and they also suffer from nausea, vomiting and poor appetite, these can cause them lack of nutrients, leading to weight loss.

* Fatigue

The patients with Membranous Nephropathy may feel tired or worn out all day long. It is mainly due to anemia.

If you want to learn more information about Membranous Nephropathy, you can consult the online family doctor.

If you have been diagnosed with Diabetic Nephropathy, we're here to help. Call us: +86-311-89261580 OR Viber/Whatsapp: +86 13503211882 or email us: through Sunday) to make an appointment.

Diabetic Nephropathy treatment

Diabetic Nephropathy is one of the most severe complications of Diabetes and also the leading cause of Renal Failure. Early inspection and treatment can slow down the disease progression and prevent the occurence of Renal Failure. This article will give you a view of treatment options for Diabetic Nephropathy.

Glycemic control

Diabetic Nephropathy is mostly likely to occur in patients who have worse glycemic control. Further, high blood glucose can accelerate the progression of Diabetic Nephropathy.

An intensive therapy to control blood glucose can reverse glomerular hypertrophy and hyperfiltration. Thus, it can delay the development of microalbuminuria and even reverse it. In early stages of Diabetic Nephropathy, controlling blood glucose can prevent kidney damage.

Management of high blood pressure

An intensive management of high blood pressure can slow the development of Diabetic Nephropathy and reduce proteinuria. The mostly used antihypertensive medications mainly include:

ACE inhibitors is superior to beta-blockers, diuretics, and calcium channel blockers. It not only can reduce urinary albumin excretion, but also has significance in preserving renal function. Additionally, ACE inhibitor is effective in slowing the progression of diabetic retinopathy and the development of proliferative retinopathy.

RAS inhibition is effective in treating Diabetic Nephropathy. It can improve glomerular permeability in patients with type 1 Diabetes, it does not do so in patients with type 2 Diabetes.

Renal replacement therapy

When Diabetic Nephropathy develop into ESRD, the patients have to take renal replacement therapy to maintain their life including dialysis and kidney transplant.

In people with Diabetic Nephropathy, they should start dialysis earlier than non-diabetics. Starting at a creatinine clearance or estimated GFR of 10~15 mL/min is wise. Dialysis only works in removing wastes from body, but is not effective in improving renal function or stopping the disease progression.

Kidney transplant can help the patients get normal renal function and prolong their life span. It is a better option for diabetics than dialysis. However, for serious complications of Diabetes, the patients are at higher risk than non-diabetics.


Recent researches shows that immune dysregulation is a major cause of kidney damage in Diabetes. Immune dysregulation can cause immune system to work abnormally and lose their protective ability. As a result, the immune system may attack kidney tissues and cells mistakenly. Immunotherapy is designed to correct immune dysregulation and control symptoms of Diabetic Nephropathy by rebuilding kidney structure.

Blood purification

Blood purification is used to remove the toxins and harmful substances from body. Compared with dialysis alone, it can give a complete removal of various toxins and wastes from body including micromolecular, middle-molecular and macromolecular waste products and immune complexes completely.

If you have been diagnosed with Diabetic Nephropathy, we're here to help. Call us: +86-311-89261580 OR Viber/Whatsapp: +86 13503211882 or email us: through Sunday) to make an appointment.

Diabetic Nephropathy diagnosis

Diabetic Nephropathy is a secondary disease of Diabetes. If renal damage is detected and treated as early as possible, you will be able to stop the disease progression and avoid developing Renal Failure. The tests are usually prescribed to people with Diabetic Nephropathy mainly include:

Routine tests:

1.Microalbumin urine test

In early stage of Diabetic Nephropathy, you may only have a small amount of protein in urine. Microalbumin urine test can detect very small amount of protein in urine that cannot be detected by a routine urine test. You are recommended to do this test within 3 to 6 month period.

2.Creatinine test

You should have a creatinine test every year. The creatinine test is a blood test that tell you how your kidneys are working.

Urine test and other blood tests

If your doctor suspect that your kidney damage is not associated with Diabetes, urine test or other blood tests may be done to find out the causes.

3.Blood pressure tests

It is important to check blood pressure for people with Diabetic Nephropathy. Blood pressure rises as kidney damage progresses. To slow down renal function aggravation, you are recommended to control blood pressure within 130/80 mmHg.

Special tests:

1.Kidney damage tests

Kidney damage tests have the following clinical significance:

※ Figure out if your kidneys are damaged.

※ Make out if the renal tubule is involved.

※ Tell the kidney damage degree to provide clinical guidance for clinical medication.

※ Evaluate if you are sensitive to the medications.

Tests for kidney damage mainly include U-TP, U-IGG,β2-M, U-malb, etc.

2.The tests for toxins in blood aim at:

※ Figure out the condition of accumulated toxins in body;

※ Determine the right clearance method to remove toxins and wastes from body. The toxins in blood mainly include uric acid, creatinine, urea nitrogen, homocysteine etc.

Blood lipid tests:

Blood lipid tests are designed to have the following clinical significances:

※ Determine if your levels of lipids increase.

※ Figure out the type of hyperlipidemia.

※ Guide to find the right method to lower levels of lipids.

Tests for blood lipids mainly include triglyceride, total cholesterol, HDL, LDL, etc. Removing extra blood lipids is important to reduce the risk of developing cardiovascular diseases and heart disease.

If you have been diagnosed with Diabetic Nephropathy, we're here to help. Call us: +86-311-89261580 OR Viber/Whatsapp: +86 13503211882 or email us: through Sunday) to make an appointment.

Diabetes is the leading cause of Renal Failure worldwide. However, not all people with Diabetic Nephropathy develop Diabetic Nephropathy.

Around 20~30% of people with Diabetes develop Kidney Disease although not all of these will progress to Renal Failure. Who are high risk of developing Diabetic Nephropathy?

Uncontrolled blood glucose

The tiny blood vessels in kidneys are responsible for filtering wastes and end products from body. If blood glucose is not controlled, the high levels of sugar in the blood will damage the millions of tiny filtering units. This eventually leads to Renal Failure. In order to reduce the risk of Diabetic Nephropathy, you should keep restrict control of your blood sugar level. You can achieve it by taking the following steps.

Diabetic Nephropathy knowledge

* Take insulin or medications regularly as the doctor told you

* Avoid foods high in sugar

* Test blood sugar level regularly


Being overweight is a main cause of Diabetes for many people. Reducing weight can reduce the need for medications to control Diabetes. If Diabetes is better controlled,the patients are less likely to get kidney disease. Therefore, it is very important for the patients with Diabetes to take steps to achieve a healthy weight. They are recommended to avoid foods high in sugar and fat and do exercise every day.

High blood pressure

High blood pressure is a complication of Diabetic Nephropathy. In return, it can worsen kidney function at a fast speed. High blood pressure makes the heart work harder, over time, can damage blood vessels in kidneys. To prevent high blood pressure or lower blood pressure, you should avoid foods high in fluids and sodium and control blood pressure within 130/80 mmHg.

Genetic susceptibility

Genetic susceptibility is an important factor in causing Diabetic Nephropathy and affecting the severity of the disease.


The incidence of Diabetic Nephropathy is also associated with race. Some studies show that the incidence and severity of Diabetic Nephropathy are in blacks, Mexican-Americans.

The above are the major risk factors of developing Diabetic Nephropathy. Some are controllable, but some are not. If you can minimize the influence of controllable risk factors, your chance of developing Diabetic Nephropathy will decline significantly.

If you have been diagnosed with Diabetic Nephropathy, we're here to help. Call us: +86-311-89261580 OR Viber/Whatsapp: +86 13503211882 or email us: through Sunday) to make an appointment.

Diabetic Nephropathy is secondary to Diabetes. Along with an effective treatment, proper health care is beneficial to slow the disease progression and improve their life quality. Health care for Diabetic Nephropathy mainly involves the following aspects:

Diabetic Nephropathy health care


The diet for Diabetic Nephropathy should guarantee ample calorie and nutrient supplement. Meanwhile, the carbohydrate, fat and protein consumption should be controlled.


Limiting protein intake is very likely to cause malnutrition. To maintain normal body weight, they are recommended to improve the intake of calorie. In their consumption of calorie, carbohydrate accounts for 55%-60%, fact covers 20%~25% and proteins sharing for 15~20%.


High levels of fat can cause arteriosclerosis. Thus, it is wise to limit the intake of fat and the patients are recommended to replace animal oil with vegetable oil. Olive oil and peanut oil are rich in unsaturated fatty acid and they are important sources of energy.


Low-salt diet can benefit the control of blood pressure as well as relieve swelling and slow kidney function deterioration. The patients with Diabetic Nephropathy are recommended to limit salt intake to 5 grams a day. Meanwhile, foods loaded in salt such as processed foods, cured foods should also be avoided.

* Protein

Even in early stages of Diabetic Nephropathy, the patients are recommended to limit the protein intake and the daily protein intake should be reduced to 0.8 g/d. If the patients are experiencing renal insufficiency and swelling, the protein intake should be limited to 0.6 g/d.

Control blood pressure

High blood pressure is complication of Diabetic Nephropathy. In return, it also can accelerate the progression of kidney disease. ARB and ACE inhibitors are common medications used to control high blood pressure. Besides controlling blood pressure, the medications are also beneficial in preserving kidney function. Even if the patients do not develop high blood pressure yet, they are recommended to take the medications.


Proper exercise can help control blood pressure and blood glucose. They should choose mild and aerobic exercise such as walking, swimming, bicycling and yoga. Meanwhile, they should limit the time and intensity of exercise to avoid hypoglycemia.

If you have been diagnosed with Diabetic Nephropathy, we're here to help. Call us: +86-311-89261580 OR Viber/Whatsapp: +86 13503211882 or email us: through Sunday) to make an appointment.

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