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Can Kidney Disease Be Inherited


2013-06-22 16:15

Can kidney disease be inherited? This is a concern for the patients who plan to get pregnant. You will get an answer from the following context.

Not all cases of kidney disease are inherited.There are still many other causes of kidney disease.The main groups of inherited kidney disease are:

Cystic kidney diseases

*Polycystic kidney disease (PKD) includes autosomal dominant polycystic kidney disease (ADPKD) and autosomal recessive polycystic kidney disease(ARPKD).

ADPKD is more common in clinic and the patients usually develop symptoms until adult.Most of children born with ARPKD die after several days of their birth.

Nephronophthisis: juvenile and adult form

Medullary Sponge Kidney: It is a congenital disorder that can affect one or both kidneys, or only part of one kidney.

Inherited metabolic diseases with kidney involvement

There is a number of inherited metabolic diseases which can involve kidneys. With glomerular involvement,eg Diabetes, genetic amyloidosis, Anderson-Fabry disease. However, diabetes just has genetic predispositions, not all children will get the disease if there is a family history.Diabetes is one of the primary causes of Kidney Disease.

Other inherited diseases, eg congenital Nephrotic Syndrome, nail-patella syndrome.

Primary immune glomerulonephritis(occasionally familial,eg IgA nephropathy).

The above are the major forms of inherited kidney disease.As some primary diseases of kidney disease like diabetes and high blood pressure have genetic predisposition, it is important for the children to prevent these conditions. if the primary diseases can be prevented, they will not get kidney disease.

As kidney disease usually develops asymptomatically, most of the patients can not notice them until very serious symptoms occur. Therefore, if there is family history of kidney disease, it is important for the family members to take regular screening. Early inspection and treatment can stop the disease from developing completely.



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