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High Fat Diet Can Cause Kidney Damage


2013-04-20 10:55

High Fat Diet Can Cause Kidney DamageA healthy diet plays such an important role in keeping kidneys healthy.High-fat diet not only can worsen renal function in kidney disease, but also can cause kidney damage to healthy kidneys.Therefore,it is essential for us to pay much care to amount of fat in our diet.

In a study, the rat is fed with high-fat feedstuff with 4% cholesterol and 1% sodium cholate.After 8 weeks’ high-fat diet,the protein in urine and fat levels elevate obviously,especially serum total cholesterol and low density lipoprotein.The fact proves that high-fat diet can cause kidney damage to the healthy kidneys.

In the further study, with the increasing of cholesterol level,the nitric oxide in urine increases obviously and nitric oxide synthase in kidneys enhances.Additionally,the super-oxide ion in body and kidneys elevate. Then nitric oxide combines with the super-oxide ion in body to form peroxide nitrite which are toxic to cells in body.

The mechanism of kidney damage caused by high-fat diet is described as:

Nitric oxide combines with super-oxide ion to form peroxide nitrite which are toxic to kidney cells, thus resulting in apoptosis.The increase of nitric oxide is associated with proteinuria.Enhancement of nitric oxide synthase and increase of nitric oxide can cause glomerulosclerosis and renal tubular interstitial damage. Another finding in the study is that nitric oxide synthesis inhibitor can prevent glomerular mesangial cytolysis and inhibit proteinuria and glomerulosclerosis.

For all patients with Kidney Disease,they must adopt lipid-lowering treatment once they develop hyperlipidemia.Also, it is important to cut down the fat in diet.In general,a low-fat diet is very important to slow renal function deterioration and protect renal function.

The intake of fat should be based on your illness condition.Then how much fat should you take each day? You can consult us to get a reference. Or you can learn more information on food&drink for kidney disease.




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