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Recurrence of FSGS after Kidney Transplant

2013-03-07 11:44

Kidney transplant is a major replacement therapy for FSGS. However, recurrence occurs in 25~53% of the patients with this glomerulopathy who receive kidney transplant and in over 80% of patients receiving subsequent transplants after previous recurrence.

Why does recurrence of FSGS occur after kidney transplant?

FSGS is an autoimmune disorder.Immune system is a powerful protective system in body and it can protect against the foreign harmful substances. However, in some cases, the immune system is activated improperly, leading to abnormal activity of immune system. The abnormal activity of immune system can cause inflammation in kidneys to cause progressive damage to kidneys.

Kidney transplant is a major surgery, in which the diseased kidney is replaced with a new kidney, but it can not correct the immune dysfunction. So the abnormal activity of immune system will attack the new kidney, thus leading to recurrence of kidney transplant after kidney transplant.

How to treat recurrent FSGS after kidney transplant?

Plasmapheresis has been shown to decrease activity of the permeability factor in the circulation and to induce remission of recurrent FSGS. Also, administration of high doses of calcineurin inhibitors, cyclophosphamide and antihypertensive drugs have been used to treat recurrent FSGS after kidney transplant. However, these drugs only can relieve the symptoms of FSGS, but are not enough to stop its progression.

Is there alternative treatment for recurrent FSGS after Kidney Transplant?

Immunotherapy is an alternative treatment for recurrent FSGS. This therapy treats the disease by suppressing the inflammation and correcting the abnormal immune system. In this way, it can stop further damage to the transplanted kidney. Additionally, it can activate the self-healing system of the body to restore the impaired kidney structure and improve renal function. Thus, it can stop the graft failure.

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