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Causes of Proteinuria and Hypertension in FSGS


2013-04-08 11:30

Proteinuria and hypertension are two major complaints of FSGS and also are significant factors in worsening renal function.What are the causes of proteinuria and hypertension in FSGS?

Causes of proteinuria in FSGS

Healthy kidneys can filter wastes from body and meanwhile preserve useful substances in body.Proteins are big enough so they can not pass through filters.However,in FSGS,the filters in kidneys are scarred and they can not work well enough.As a result,a large amount of proteins will pass through filters and end up in urine.When there is excess protein in urine, the urine will become foamy.

Proteins can hold fluid in blood vessels and are important antibodies in body.Loss of proteins can cause weak immunity and swelling. So the patients with FSGS are susceptible to infection.

As for the treatment for proteinuria in FSGS, the patients should limit consumption of foods high in protein.ACE inhibitor and ARB drugs can help lower proteinuria and protect the renal function.

You can learn detailed information about treatment for proteinuria in FSGS.

Causes of hypertension in FSGS

Kidneys play an important role in maintaining blood pressure.They can filter excess fluids to maintain constant blood volume and also can produce a kind of hormone which can regulate blood vessels.

However,in FSGS,the diseased kidneys fail to work normally. Consequently,excess fluids build up in body to raise blood pressure. Additionally,due to renal ischemia and anoxia, more renin which can regulate blood pressure will be produced.It can contract blood vessels indirectly, thus resulting in high blood pressure.

To treat hypertension in FSGS, one is to remove excess fluids from body. Another is to correct the secretory function of the kidneys. As mentioned above,ACE inhibitor and ARB drugs are classic medications for hypertension. Also, the patients should keep fluid restriction and take medicines to help the excretion of fluid.

The above are the causes of proteinuria and hypertension in FSGS. As both of the conditions result from FSGS itself, the ultimate treatment goal is to treat the disease fundamentally.




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