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Steroid Treatment for FSGS


2013-01-25 17:01

Focal segmental glomerulonephritis( FSGS) is a very hard condition to treat. It is a disorder that attacks the kidney’s filtering system causing serious scarring of kidney tissues and a large amount of protein leakage in urine. FSGS is a common cause of Nephrotic Syndrome.

Steroid treatment is commonly prescribed to treat FSGS. Prednisone is often given to control proteinuria. It can reduce the permeability of blood capillaries and cell membrane to reduce the protein leakage. However, steroid treatment alone is not enough to treat FSGS at all. Meanwhile, long-term dependence on steroid can bring a number of side effects.

Apart from steroid treatment, your nephrologist may also recommend the following drugs and treatments.

* Immunosuppressive agents to suppress activities of immune system.

* Diuretics and low salt diet to reduce retention of fluids and control edema.

* ACE inhibitor or ARB is prescribed to control high blood pressure.

* Anticoagulants to prevent blood clots and stains to lower the cholesterol levels.

However, the above treatments are not treat FSGS from it root causes, so it is unable to stop it from progressing into renal failure. It is the secondary leading cause of Kidney Failure in children. About half of FSGS patients who do not respond to steroid treatment go into ESRD each year, requiring dialysis or transplantation.Approximately 1,000 FSGS patients a year receive kidney transplants. However, within hours to weeks after a kidney transplant, FSGS returns in approximately 30-40% of patients. Therefore, alternative aggressive treatment is required to control FSGS and stop it from developing into renal failure.

Immunotherapy is an alternative treatment for FSGS. It aims at suppressing the abnormal immune system activities and correcting immune dysfunction. Meanwhile, it can stimulate the self-repairing of the impaired filtering system of kidneys to improve renal function. As immunotherapy can treat FSGS from its underlying causes, it can bring the patients a better recovery than steroid treatment.




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