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Type 1 VS Type 2 Hepatorenal Syndrome


2012-10-24 18:21

Hepatorenal Syndrome is divided into two types--Type 1 and Type 2. There are various differences between the two forms. Read on and find the differences.

Type 1 Hepatorenal Syndrome

Type 1 Hepatorenal Syndrome is also known as acute hepatorenal syndrome. Kidney Failure appears in severe liver problems and develops rapidly in this type. Acute Kidney Failure progression is the characterized clinical symptoms. And usually the serum creatinine levels will double within 2 weeks and the final serum creatinine levels >2.5mg/dl or the Ccr reduces by 50% and the final levels Ccr<20ml/min within 2 weeks.

Usually, the prognosis of type 1 hepatorenal syndrome is very bad and the death rate within 2 weeks is as high as 80%. In this type, if the liver condition can reverse, the kidney function will increase spontaneously. Thereby, it is important to find the cause of liver problem, such as acute liver failure or alcoholic hepatitis and acut decompensated cirrhosis.

Patient may die from kidney failure complicated with liver failure or liver failure complicated with visceral hemorrhage.

Blood purification, such as dialysis, blood plasma exchanges are suggested as emergency treatment for type 1 hepatorenal syndrome. Other treatments may also include liver transplant, injecting medicines of albumin, kidney transplant.

Type 2 Hepatorenal Syndrome

This type usually happens in patients with Diuretic Resistance. Renal failure develops slowly and usually kidney function decline progresses fro more than several years. The lifespan of type 2 hepatorenal syndrome is longer than that of type 1, but it also leads to poor prognosis.

The cause of type 2 hepatorenal syndrome may include advanced decompensated liver cirrhosis or other severe liver disorder. It also can happen without no triggers and in clinic, the common cause are bacterial infection, abnormal plasma volume expansion treatment and alimentary tract hemorrhage etc.

Treatments for type 2 hepatorenal syndrome include liver transplant, diuretic, injection of albumin, limitation of water consumption in low blood Na level and TIPS etc.


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