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What Causes IgA Nephropathy


2012-10-26 18:02

IgA Nephropathy is a Glomerulonephritis in which the immune system releases extra immunoglobulin A (IgA) and causes kidney damages. What causes IgA Nephrpathy?

IgA Nephropathy is an autoimmune disease in which underlying immune disorder produces immune complexes in the blood that causes kidney impairment by triggering excessive inflammation.

In other words, the root cause of IgA Kidney Damage is immune disorder. Thereby, only treatment that deals with this problem can offer the chance to cure IgA Nephropathy.

Immunity and IgA production

One of import from of IgA is called secretory IgA, which exists in the tonsil, genitourinary tract, gastrointestinal tract, prostate and respiratory epithelium etc. All of these areas are associated with immune system closely.

If you have immune disorder or low immunity, infections will easily happen in this organs or tissues, such as tonsil, urinary tract etc, which will cause excessive IgA are produced. This causes deposition in kidneys and kidney damages.

This is why someone jokes that: “A cold or A mild infection can kill me—A IgA Nephropathy patient. In other words, immune disorder is the root cause of IgA Nephropathy. Thereby, a key treatment is to improve immunity and rebuild immune system in IgA Nephropathy patients.

Besides the underlying cause of IgA Nephropathy—Autoimmune disorder, other additional factors may make you at higher risk to develop IgA Nephropathy.



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