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Can Tonsillectomy Cure IgA Nephropathy


2012-09-30 16:58

IgA nephropathy is one of common glomerulonephritis due to immune dysfunction.Tonsillectomy is generally suggested to the patients and it has effects in reducing the episodes of hematuria and proteinuria. However, tonsillectomy can not cure IgA nephropathy at all.

IgA nephropathy is due to IgA depositions in kidneys. It has been proposed that tonsils are a source of abnormal IgA that forms immune complexes and deposits in the glomeruli. Tonsillectomy removes tonsil so as to reduce the production of IgA and limit the degree of kidney damage. In this way, it can reduce the recurrence of the disease. However, tonsillectomy alone is not enough to manage IgA nephropathy. Other treatment options mainly include:

Mediations

Angiotensin-converting enzyme inhibitors( ACE inhibitors) can help to reduce blood pressure and decrease protein loss in urine. It is usually prescribed to the patients with proteinuria even if they do not have high blood pressure.

Fish oil

Fish oil contains omega-3 fatty acids. This kind of substances can suppress the inflammatory response in glomeruli, thus slowing the progression of the disease.

Dietary changes

Dietary changes play a crucial role in managing IgA nephropathy. You should reduce salt and limit the amount of protein in your diet.

Immunosuppressive therapy

Inflammation of glomeruli is cause of kidney damage in IgA nephropathy. Immunosuppressive therapy like glucocorticoid therapy. This therapy can suppress the inflammatory response and reduce the incidence of renal events significantly. However, the disease is very likely to relapse.

Immunotherapy

Immunotherapy is a new treatment option for IgA nephropathy. It can correct immune dysfunction to stop the production of IgA immune complexes. Thus, it can prevent further inflammatory injury to kidneys. Additionally, it can stimulate the regeneration of renal functional cells to restore the impaired kidney structure and improve renal function.

As not all patients with IgA nephropathy can take tonsillectomy, you should consult your doctor before you undergo it.




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