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What Are The 5 Common Types Of Hereditary Nephropathy


2019-04-29 15:16

Hereditary Nephropathy,Common TypesMost Chronic Kidney Diseases are not hereditary diseases, but in most nephrotic diseases, genetic problems are one of the causes. Even some kinds of nephropathy belong to hereditary diseases, which are often difficult to treat.

Five relatively common types of hereditary nephropathy are introduced today.

1. Polycystic Kidney Disease

The most common hereditary nephropathy. According to statistics, there are about 1.5 million to 3 million patients with polycystic kidney disease in China. Many drugs have been used in the treatment of polycystic kidney, such as rapamycin target protein inhibitor, somatostatin, V2 receptor antagonist and so on. However, due to the failure to delay the progress of renal function damage, aggravate renal ischemia, cause liver damage and other reasons, the ultimate result is often not ideal.

Polycystic kidney not only develops to renal failure and uremia in more than half of patients, but also causes polycystic liver, pancreatic duct and bile duct dilatation, colonic diverticulum, intracranial aneurysm, heart valve abnormalities and other diseases.

At present, polycystic kidney is best treated by traditional Chinese medicine, which can control the growth of cysts to a certain extent.

2. Alport Syndrome

Also known as hereditary glomerulonephritis, is a hereditary glomerular basement membrane disease in patients with impaired glomerular basement membrane.

At present, there is no drug to improve the damage of collagen type 4 in the basement membrane of Alport syndrome, and the patients often develop to uremia in young adults.

3. Fabry's disease (Fabry's disease)

Also known as diffuse cutaneous angiokeratoma, it is a hereditary disease.

Renal damage can occur with age. At present, enzyme replacement therapy is widely used (expensive). Renal failure is the most common and serious complication.

4. Congenital nephrotic syndrome

Nephrotic syndrome (massive proteinuria, hyperlipidemia) occurs within three months of birth, and even symptoms occur in the uterus. Hormones and immunosuppressants are ineffective, and the only treatment is kidney transplantation.

5. Thin basement membrane nephropathy

Also known as benign familial hematuria, is a less harmful kidney disease. The patient's glomerular basement membrane thinned, resulting in occult blood leakage in urine.

Most patients with thin basement membrane nephropathy (TBMN) are asymptomatic and often have microscopic hematuria for other purposes. Some patients have mild proteinuria, which usually does not damage renal function.

In short, most of the hereditary nephropathy is difficult to treat, and the risk of renal failure and uremia is relatively high. Diuresis, hypotension and symptomatic treatment should be given to minimize renal damage.

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