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Relationship of Glomerular Filtration Rate (GFR) And Creatinine


2012-11-30 16:50

Nearly all patients with kidney disease are very sensitive to creatinine, but not all of them know much about glomerular filtration rate(GFR). In fact, compared with creatinine, GFR is a more accurate indication of renal function. What is the relationship between creatinine and GFR?

Firstly, the article will give you an explanation about creatinine and GFR.

Creatinine is the byproducts of creatine in blood and it is normally filtered out of body by kidneys. Therefore, the level of creatinine remains fairly constant in blood. In general, the creatinine level ranges between 0.6 to 1.2 mg/dL. The value is a little different from hospital to hospital as their reference level varies. As creatinine reflects renal function, its level does not increase until kidneys have been damaged badly.

GFR is used to the check how well the kidneys are working. Each kidneys contain 1 to 2 million glomeruli which are the filtering units in kidneys. In right condition, the blood is filtered by glomeruli to excrete wastes and produce urine. Specially, GFR estimates how much blood passes through the tiny filters in the kidneys each minute. A lower than normal GFR usually means that the kidneys have been impaired.

GFR describes the excretory function of kidneys in eliminating creatinine and other metabolic wastes. For powerful compensatory ability of kidneys, creatinine level does not elevate until GFR has been halved. A three times high than normal creatinine level means that you only have 25% of kidney function left. The higher GFR is, the lower creatinine level will be.

Therefore, in treating kidney disease, reducing creatinine level should not be the ultimate treatment goal. Increasing GFR should be the primary goal in treating kidney disease.




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