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How Is the Prognosis of Lupus Nephritis

2012-09-15 17:28

Lupus Nephritis refers to inflammation of the kidneys that is caused by systemic lupus erythematosis (SLE). The prognosis of Lupus Nephritis varies from case to case.

The prognosis of Lupus Nephritis is mainly associated with the following factors.

High blood pressure

High blood pressure can make the kidneys work harder. Over time, it can damage blood vessels throughout the whole body. The tiny blood vessels in kidneys are responsible for filtering blood. If the blood vessels are impaired, the filtering ability of kidneys will reduce significantly. To slow prognosis of Lupus Nephritis, controlling blood pressure within normal level( 130/80mmHg) can improve its prognosis.

Massive proteinuria

Proteinuria has toxity, it can cause direct damage to glomerular mesangial cells and renal tubular, thus deteriorating renal function. Meanwhile, proteinuria can cause renal tubular anoxia, resulting in tubular impairment.

High activity index score of SLE

Frequent activity of SLE is a risk factor in worsening Lupus Nephritis. It can increase the production of immune complexes which are trigging factor of inflammation in glomeruli. Therefore, avoiding relapse of SLE is very important to improve prognosis of Lupus Nephritis. The patients should avoid sunlight, allergen and some certain foods which can cause allergy like shrimp.


Complications can worsen the prognosis of Lupus Nephritis significantly, including cardiovascular disease and thrombotic events. Also, the therapy with corticosteroids, cyclophosphamide, and other immunosuppressive agents increase the risk of infection and other problems. These are all risk factors for worsening prognosis of Lupus Nephritis.

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