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Treatment of Membranous Lupus Nephritis with Nephrotic Syndrome

Provided by Expert Zhang Youkang on 2013-06-14 14:54

Lupus nephritis is one of the most serious complications of systemic lupus erythematosus (SLE).Based on the kidney damage degree and pathological changes,lupus nephritis can be divided into 5 classes. Lupus membranous nephritis the class V of lupus nephritis.

SLE is an autoimmune disease. This means there is a problem with the body’s immune system. Normally, the immune system can protect the body from harmful substances. However, in SLE, the immune system fails to tell the difference between harmful substances and healthy tissues and cells in body. As a result, the immune system attacks the healthy cells and tissues in body by mistake. It can involve multiple organs and systems, such as skin, nerve, brain, kidney. About half will have some form or degree of kidney involvement. If you are a patient with lupus, are you at the risk of Lupus Nephritis? You can consult us to know what tests you should do to know if you are at risk.

When the immune system attacks the kidneys, it can cause inflammation of filters called glomeruli in kidneys. In normal condition, the glomeruli can filter blood, but retain useful substances in body. However, when the glomeruli are impaired, a lot of proteins will leak into urine, resulting in protein in urine and Nephrotic Syndrome. If the patients with membranous lupus nephritis, it is usually associated with a poor prognosis.

What is the treatment for membranous lupus nephritis with nephrotic syndrome? It is typically treated with high doses of corticosteroids, with or without immunosuppressive drugs.However,these medicines only can suppress the abnormal immune response temporarily, but can not stop the disease progression.

As the underlying cause of membranous lupus nephritis is autoimmune disorder, the primary goal of treatment should be rebuild the normal immune system. In this way, it can stop further immune damage to kidneys completely. Furthermore, glomeruli are impaired, thus resulting in nephrotic syndrome. If the glomeruli can be restored to function well, nephrotic syndrome will be controlled fundamentally. Immunotherapy can help the patients get the above treatment goals. You can consult us on line to get more detailed information about the therapy.

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