Creatinine is a by-product of creatine. Normally, it is filtered out of body by kidneys so it keeps at a constant level. The creatinine level is used to determine how the kidneys are functioning. Certain drugs can cause elevated creatinine level.
Diuretics can promote the excretion of sodium and water to reduce blood volume. It can help lower high blood pressure and relieve swelling. However, long-term use of diuretics can cause the kidney’s to work overtime trying to compensate. It can cause an increase in sodium resorption which further leading to elevated creatinine level.
Non-steroidal anti-inflammatory drugs(NSAIDs)
NSAIDs can kill pain, lower fever, suppress inflammation etc. It is extensively used in clinic. However, long-term use of NSAIDs can cause interstitial nephritis. Because of this side effect these drugs are listed a possible cause of elevated creatinine.
Cyclosporine A is commonly to used to prevent organ rejection after transplant. It is also effective in treating some immune diseases. However, possible side effects of cyclosporine A include elevated creatinine. The patients who are taking these drugs should concern their creatinine level.
The chemotherapy drugs for cancer are associated with elevated increased creatinine level. Often, it only cause temporary increasing in creatinine level, but sometimes it can be permanent. As the risk of kidney failure is very real among people who are receiving chemotherapy, it is important for the doctor to monitor the patients during the treatment.
Antibiotics also can damage kidney and cause elevated creatinine level.
The above are the common drugs which can cause elevated creatinine. If you are taking those drugs over time, you should be monitored by your doctor closely.