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How to Treat Proteinuria for Membranous Glomerulonephritis

2013-12-18 14:55

How to Treat Proteinuria for Membranous GlomerulonephritisFor patients with membranous glomerulonephritis, or membranous nephropathy, they usually find their proteinuria, because there is foam or bubble in their urine. Why does membranous glomerulonephritis cause foamy urine? How to treat it?


Membranous glomerulonephritis is characterized by a large amount of immune complexes depositing in glomerular epithelial cells. Therefore, this type of kidney disease mainly causes damage to glomeruli. When these kidney filters can’t do their job properly, a lot of protein is more likely to leak from kidneys into urine, forming proteinuria. In most cases, 24h-protein urine of membranous glomerulonephritis is more than 3.5g/d but less than 15g/d.


According to patients’ illness condition, different patients need to take different treatment options. If their 24-h protein urine is less than 3.5g/d and kidney function is normal, they can take the following methods:

- Control high blood pressure: ACEi and ARB are recommended firstly for these patients.

- Anticoagulant therapy: It is used to prevent the formation of phlebothrombosis.

- Low-protein diet: Patients who have heavy proteinuria had better restrict their protein intake at about 0.8g/kg every day. At the same time, they should take in enough calorie and the total amount is about 146.54 kj (35kcal)/kg one daily.

If their urine tests shows proteinuria is above 3.5g/d accompanied with decline of kidney function or proteinuria is above 8g/d, doctors may recommend steroids, cytotoxic drugs or immunosuppressants for membranous glomerulonephritis patients. In most cases, these medications can help relieve proteinuria obviously, by inhibiting immune reactions. However, they are able to manage membranous glomerulonephritis completely.

To treat proteinuria from the root, Immunotherapy is worth a try, because it can not only regulate immune system but also remove immune complexes out of the body. Without pathogenic factors depositing in the glomeruli, ,membranous glomerulonephritis can be controlled very well, let alone proteinuria.

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