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The Definition and Symptoms of Membranous Nephropathy

Provided by Expert Zhang Youkang on 2015-02-12 09:24

The Definition and Symptoms of Membranous Nephropathy The Membranous Nephropathy is a noun of pathomorphism diagnosis and is a common pathogeny. The characteristic pathological alteration is that large number of immune complex deposition in the capillary loops of epithelial side of glomerulus. The clinical manifestation is nephritic syndrome (lots of proteinuria, hypoproteinemia, heavy edema, hyperlipemia), or asymptomatic and not belong to the nephritic range proteinuria. If you have any questions please ask our ONLINE DOCTOR directly for free.

The Membranous Nephropathy is divided into the idiopathic and secondary membranous nephropathy according to the aetiological agent.

idiopathic membranous nephropathy

Most of it related to the phospholipase A2 receptor antibodies, phospholipase A2 receptor antibodies combined with the corresponding antigen of podocyte, which forms original site immune complex glomerulonephritis, then through the alternative pathway to complement activation and C5b-9 membrane attack complex, injuring podocyte and destroying GFR, forming proteinuria.

The secondary Membranous Nephropathy

It occurs to many systematic diseases in secondary phase, such as systematic lupus erythematosus, rheumatoid arthritis, hepatitis b virus infection. Because of the drugs, toxicant things, tumor or environment reasons. The drugs of leading the secondary membranous nephropathy have gold salt, mercury, penicillamine and ibuprofen and diclofenac.

The clinical manifestation is nephritic syndrome (lots of proteinuria, hypoproteinemia, heavy edema, hyperlipemia), or asymptomatic and not belong to the nephritic range proteinuria, microscopic hematuria with a few blood urine, some patients with high blood pressure or kidney function injure.

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