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Membranous Nephropathy

Definition

Membranous Nephropathy is a medical condition, in which the small blood vessels responsible for filtering blood are inflamed and thickened. As a result, the proteins in body pass through the damaged blood vessels and end up in urine( proteinuria). In many cases the protein loss can eventually Nephrotic Syndrome featured with high amount of protein loss, swelling, hypoproteinemia and hyperlipidaemia.

In a tiny proportion of cases, the disease can remit. As the level of protein leakage increases, so does the risk of long-lasting damage. In as many as 40% cases, the disease eventually leads to Renal Failure.

Symptoms

Membranous Nephropathy can develop asymptomatically for years without being noticed. As more protein leak into urine, you may notice swelling in your legs and ankles and weight gain from excess fluid. Most people do not have any severe symptoms until their kidneys are damaged significantly. Signs and symptoms include:

Membranous Nephropathy basics

* Swelling in the legs and ankles

* Weight gain

* Fatigue

* Poor appetite

* Sleep problem

* Increased urination at night

* Blood clots

* Infections

* Foamy urine

Causes

Membranous Nephropathy is an autoimmune disease. In right condition, your immune system can protect your body against foreign harmful substances. However, in some cases, the immune system can not work well and mistakes your kidney tissues as foreign invaders and attacks them with autoantibodies. In Membranous Nephropathy, the autoantibodies damage to glomeruli to cause renal function decline.

Risk factors

The risk factors for Membranous Nephropathy mainly include:

* Some conditions and diseases can increase the risk of developing Membranous Nephropathy such as lupus and other autoimmune diseases.

* Some medications are causes of Membranous Nephropathy, mainly including nonsteroidal anti-inflammatory drugs and gold salts.

* Certain infections can increase the risk of the disease, such as the hepatitis B, hepatitis C and malaria.

The above are the basics about Membranous Nephropathy. If you are wondering to get more information about the disease, our online family doctors may help.

If you have been diagnosed with Membranous Nephropathy, we're here to help. Call us: +86-311-86954186 OR Email us: kidneyabc@hotmail.com(Monday through Sunday) to make an appointment.

Membranous Nephropathy symptoms

Membranous Nephropathy is also known as Membranous Glomerulonephritis. It is a kidney disorder that causes the changes and inflammation of the filtering system( glomeruli) in kidneys. It mainly presents the following signs and symptoms.

Edema

Edema can be seen in any area of the body. As the kidneys fail to balance the levels of fluids and minerals in body, retention of fluids and sodium can occur, leading to edema. In early stage, it mainly occurs in eyelids, ankles and gradually spread to other body parts.

Foamy appearance of urine

As the filtering system is impaired, a large amount of proteins pass through glomeruli and end in urine. Protein loss is commonly seen in Membranous Nephropathy and 80% of patients develop Nephrotic Syndrome( proteinuria>3.5g/24h, serious edema, hypoproteinemia and hyperlipidaemia).

Excessive urination at night

Renal tubule is responsible for concentrating and diluting urine. However, in Membranous Nephropathy, when the tubule is involved, excessive urination at night will occur. In normal condition, people usually go to toilet at night less than two times and average urine output is 300~400ml accounting for 1/4~1/3 total urine output in 24 hours. If you go to toilet frequently for no clear reason, you should figure out if it is related to kidney problem.

High blood pressure

High blood pressure is not so common among patients with Membranous Nephropathy and occurs in about 30% cases. It is mainly attributable to two factors. Firstly, retention of fluids and sodium can increase the blood volume. Secondly, RAS is stimulated by renal ischemia and anoxia, elevating blood pressure.

Weight gain

Weight gain is mainly due to building up of fluids in body. Generally, diuretic is prescribed to help remove extra fluids from body.

Fatigue

You may feel very tired all day long and have no energy to do your job. It is mainly associated with anemia and poor appetite.

The above are the general symptoms of Membranous Nephropathy. If you have one or several symptoms above, you should consult your doctor if they are related to kidney problem.

If you have been diagnosed with Membranous Nephropathy, we're here to help. Call us: +86-311-86954186 OR Email us: kidneyabc@hotmail.com(Monday through Sunday) to make an appointment.

Membranous Nephropathy treatment

The treatment goal of Membranous Nephropathy varies from your medical condition and the kidney disease stages that you are in. The current treatments for membranous nephropathy include hormone therapy, Traditional Chinese Medicine, Immunotherapy, Dialysis and Kidney Transplant.

Hormone Therapy

- Controlling the blood pressure with the help of medicines that block the angiotensin II system, such as ACEI.

- Decreasing the edema with the help of diuretics.

- Using statin medications to control cholesterol levels

Traditional Chinese Medicine

Traditional Chinese Medicine has a long history more than 2500 years. It uses natural ways to repair the damaged organs and tissues, and improve kidney functions. It mainly involves herbs, plant and a few animal parts. It takes effects slowly, but it has very low side effects. It has various forms of the treatments, such as medicated bath, Chinese herbal medicine, Micro-Chinese Medicine Osmotherapy and acupuncture etc.

Immunotherapy

Immunotherapy is a systematic therapy which not only repairs the damaged kidney tissues, but also rebuilds the immune system. Why rebuilds immune system? According to the latest research, almost membranous nephropathy is caused by the abnormal immune system which causes kidney damages generally. This therapy aims avoiding the relapse of the kidney disease.

Dialysis

When membranous nephropathy develops Kidney Failure, dialysis or kidney transplant may be suggested by your doctors. In this stage, kidneys cannot remove the toxins in the body properly and dialysis is used to replace the kidneys to perform the function. However, if you are on dialysis for long time, you may experience various side effects.

Kidney Transplant

Kidney transplant always is the last choice for patients. Kidney transplant uses a donated kidney to replace the failed kidney to work. After kidney transplant, patients need to take immunosuppressive agents to protect the donated kidneys from your immune system attack. If you cannot find a donated kidney from your family, you may need to wait for a very long time.

If you have been diagnosed with Membranous Nephropathy, we're here to help. Call us: +86-311-86954186 OR Email us: kidneyabc@hotmail.com(Monday through Sunday) to make an appointment.

Membranous Nephropathy diagnosis

An accurate diagnostic result is a premise for the following treatment. If you are inspected to have Membranous Nephropathy, the following tests usually are prescribed to get a confirmed diagnosis and evaluate your illness condition.

Routine testes

* Urine tests to measure the amount of protein in your urine

* Glomerular filtration rate (GFR) to measure your renal function

* A kidney biopsy to establish the diagnosis of Membranous Nephropathy and to distinguish it from other diseases

* Blood tests to look for evidence of infections or autoimmune disorders that may be related to Membranous Nephropathy and levels of creatinine and urea nitrogen.

Special tests: these tests items may not be available in your local hospitals, but they are very important to guide the following treatment.

Kidney damage tests

Kidney damage tests have the following clinical significance:

※ Figure out if your kidneys are damaged.

※ Make out if the renal tubule is involved.

※ Tell the kidney damage degree to provide clinical guidance for clinical medication.

※ Evaluate if you are sensitive to the medications.

Tests for kidney damage mainly include U-TP, U-IGG,β2-M, U-malb, etc.

Urine protein electrophoresis test

Urine protein electrophoresis test is used to analyze the the urine protein component. It is designed:

※ Find out the source of protein in urine.

※ Evaluate if you are sensitive to medications you are having.

※ Distinguish it from other kidney diseases.

Urine protein selective index

Detection purposes of this test are as follows:

※ Tell the type of Glomerulonephritis.

※ Evaluate the prognosis of the disease.

※ Give guidance to clinical medication.

When SPI≤0.1, it is high selective urine protein. It shows that glomeruli only have mild damage and you are sensitive to hormone and immunosuppressive drugs. It implies a good prognosis.

When SPI >0.2, it is non-selective urine protein which implies severe kidney damage. Generally, the prognosis of the disease and reaction to medications are bad.

Complement in blood serum tests

The tests have two clinical significances. Firstly, it can tell the degree of complement activation and it is a sign of kidney disease activity. Complement tests include five items: C3,C4,CH50, C1q, B factor.

Toxins in blood tests

The tests for toxins in blood aim at:

※ Figure out the condition of accumulated toxins in body;

※ Determine the right clearance method to remove toxins and wastes from body. The toxins in blood mainly include uric acid, creatinine, urea nitrogen, homocysteine etc.

The above diagnosis and tests can give you a comprehensive diagnosis and provide important guidance for making treatment plan and clinical medications.

If you have been diagnosed with Membranous Nephropathy, we're here to help. Call us: +86-311-86954186 OR Email us: kidneyabc@hotmail.com(Monday through Sunday) to make an appointment.

Membranous Nephropathy knowledge

When patients are diagnosed with Membranous Nephropathy, they begin to worry about some topics, such as pregnancy, life expectancy, sexual life etc. Read on and find more information about the hot topic.

Pregnancy

"Can I have a baby with membranous nephropathy?" This is many patients questions, who want a baby. Whether you are suggested to have a baby or not, depends on your own medical conditions.

Conditions that you can have a baby: your conditions is stable; you have not take medicines for about 3 years; your doctor's permission.

Conditions that you cannot have a baby: your disease is in active stage; your kidney function is very low; you are suffering from serious complications, such as heart disease, liver disease and malignant high blood pressure; you are taking chemical treatments;

If your conditions become worse and dangerous, you are suggested to perform cesarean on the conditions that your fetus is older than 7 months. Otherwise, you need to have a talk with your doctor as soon as possible.

Life Expectancy

Life expectancy of membranous nephropathy patients depends on your individual conditions. However, after years' research, experts find the general development rule of the disease, which affects life expectancy a lot.

- About 25% of patients can recover spontaneously from the disease. But you are not suggested to stop treatment, because nobody makes sure that you are the one of the 15%.

- In many patients, the proteinuria may last very long and kidney function drops constantly. Over time, it develops Nephrotic Syndrome, which may go and come for years.

- After the development of Nephrotic Syndrome within 5 years, you may develop into kidney failure stage. Generally speaking, membranous nephropathy will develop into kidney failure within 20 years. Kidney Failure will affect your life in many aspects, including your life expectancy.

If you have been diagnosed with Membranous Nephropathy, we're here to help. Call us: +86-311-86954186 OR Email us: kidneyabc@hotmail.com(Monday through Sunday) to make an appointment.

Membranous Nephropathy diet

Diet for Membranous Nephropathy

Membranous Nephropathy is featured with the inflammation of filtering system in kidneys which can diminish their ability to filter blood and excrete wastes from body. Therefore, the patients should pay more attention to what they eat so as to reduce strain on kidneys.

Fat and cholesterol restriction

Protein loss from blood can cause hyperlipidaemia in Membranous Nephropathy. A low fat and cholesterol diet can reduce the risk of cardiovascular events significantly. Saturated fats should be avoided as well as foods high in cholesterol. This includes foods like eggs, whole milk, butter, fatty cuts of meat and fried foods.

Vitamin D supplement

In Membranous Nephropathy, the ability of the kidney to synthesize 1,25-dihydroxyvitamin D is reduced. Therefore, vitamin D supplement is recommended to the patients. In the kidney, vitamin D can be converted to 1,25-dihydroxyvitamin to make up for its insufficiency.

Protein restriction

After protein is digested, it can produce a waste product called urea. Urea can travel to kidneys through bloodstream and then is filtered out of body by kidneys. If you have Membranous Nephropathy, the kidneys cannot remove urea from the blood properly. Urea in the blood can put strain on kidneys and worsen kidney condition. You are recommended to consult a dietitian to determine exactly how much protein you need to take each day.

Limit consumption of salt

High intake of salt can cause or deteriorate retention of fluids and sodium, thus deteriorating swelling. The patients with Membranous Nephropathy are recommended to consume no more than 1.5 g of sodium a day. You should reduce the intake of foods high in sodium, such as canned foods, cured foods, snack foods, processed foods, etc.

Fluids

In the later stages of Membranous Nephropathy, you need to restrict the fluid intake strictly. When kidneys are damaged, they are unable to filter out excessive fluids from body, leading to building up of fluids in body. This problem can cause edema and cause or deteriorate high blood pressure. The amount of fluid you are allowed to consume depends your level of kidney function.

If you have been diagnosed with Membranous Nephropathy, we're here to help. Call us: +86-311-86954186 OR Email us: kidneyabc@hotmail.com(Monday through Sunday) to make an appointment.

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