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Proteinuria And Puffiness in MPGN in Children

2013-07-16 10:37

Proteinuria and puffiness are commonly seen in MPGN in children. Especially,proteinuria is a very dangerous accelerator of the condition progression.How these symptoms occur? How to deal with them?

In normal conditions,the kidneys can remove wastes from body, but preserve useful substances in body.The proteins are in big size so they can not leak through the filters in kidneys.However,when the filters are inflamed,the filters can not work well. As a result, the proteins will pass through filters and end up in urine, resulting in proteinuria. When there is extra protein loss in urine,the urine will become foamy.

As for puffiness,it is mainly due to two causes.Firstly,the extra fluid in body can not removed by the kidneys as its should because the kidney function declines.In addition,proteinuria can contribute to puffiness.Proteins in blood vessels act as a sponge and they can hold fluid in normal condition. However, when the filters are impaired, a large amount of proteins will become lost in urine.As a result, the fluid in blood vessels will infilter into tissues space, resulting in edema.This puffiness is usually seen around the eyes,tummy, feet and legs, and causes weight gain.

How to deal with proteinuria and puffiness in MPGN?

*A group of medicines called ACE( angiotensin converting enzyme) inhibitors and ARBs (angiotensin receptor blockers) are used to reduce the protein loss and also to treat blood pressure.Occasionally diuretics are prescribed to reduce the puffiness.

Additionally, dietary changes play an important role in manage proteinuria and puffiness in MPGN in children.A diet low in protein and fluid is recommended to the patients.

As mentioned above,the underlying cause of proteinuria and extra fluid building is due to impaired filters in kidneys.Therefore,the underlying treatment goal is to restore the impaired filters and enhance renal function. Immunotherapy and Micro-Chinese Medicine Osmotherapy can help the patients achieve the treatment goal.

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