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Treatment for Type 1 MPGN (Membranoproliferative Gomerulonephritis)

2013-01-07 14:19

Membranoproliferative Gomerulonephritis (MPGN) is a form of glomerulonephritis. It affects the glomeruli of the kidneys. There are three types of MPGN, in which type 1 MPGN is most common.

How does type 1 MPGN occur?

MPGN is caused by an abnormal immune response with deposits of immune complexes in glomerular capillaries. Immune complexes are combinations of antigens and antibodies which bind to each other and then become lodged in the kidney. In type 1 MPGN, discrete immune complexes are found in the mesangium and subendothelial space. This activates the immune system, which causes inflammation and damage to the kidney itself. As the filters in kidneys are damaged, some proteins and red blood cells will leak through kidneys, resulting in protein and red blood cells in urine.

What is the treatment of type 1 MPGN?

Most instances of type 1 MPGN are caused by other diseases, such as systemic lupus erythmatosis (SLE), chronic infection etc. If the primary disease and condition is controlled, MPGN will relieve.

Additionally, immunosuppressive therapy and steroids are usually used to treat type 1 MPGN. They can suppress the immune system to control proteinuria.

The above treatment can relieve the symptoms of type 1 MPGN. However, they are not able to eliminate the immune deposits in kidneys. If the triggers appear again, the inflammation in kidneys will recur. Is there any other alternative treatment to type 1 MPGN?

Immunotherapy is another treatment option for people with the condition. Firstly, this therapy can suppress the inflammation in kidneys effectively and rapidly, thus stopping further immune damage to kidneys. Secondly, it can degrade the immune deposits in kidneys and dissolve them in blood. Then, they will be filtered out of body in urine. Thirdly, it can correct immune dysfunction and prevent the formation of immune complexes. Finally, immunotherapy can control the symptoms of type 1 MPGN by activating the self-repairing system in kidneys and improving renal function.

Immunotherapy can treat type 1 MPGN from both of symptoms and root causes. It can bring the patients a complete recovery.

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