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What’s Reason for Diabetic Nephropathy Patients

Provided by Expert Zhang Youkang on 2015-05-20 17:00

What’s Reason for Diabetic Nephropathy PatientsDiabetic Nephropathy is also known as Kimmelstiel–Wilson syndrome. The word diabetes means "passing through", referring to the polyuria (abnormal increase of urine production), a symptom historically present in those affected by the disease. When the level of blood glucose rises beyond the kidney's capacity to reabsorb glucose from the renal ultrafiltrate, glucose remains diluted in the fluid, raising its osmotic pressure and causing more water to be carried out, thus, increasing the excreted urine volume.

The increased volume dilutes the sodium chloride in the urine, signalling the macula densa to release more renin, causing vasoconstriction, a survival mechanism to retain water by passing less blood through the kidneys. Because the kidney is nurtured exclusively by the blood it filters, the vasoconstriction also reduces the nutrients supplied to it, causing infarct of its tissues and reduction of renal function. If you have any question please ask our ONLINE DOCTOR. We will give professional guidance as soon as possible.

Diagnosis is based on the measurement of urinary albumin. We can define:

Normoalbuminuria: urinary albumin excretion <30 mg/24h, it is the physiological state;

Micro-albuminuria: urinary albumin excretion in the range of 30–299 mg/24h;

Clinical (overt) albuminuria: urinary albumin excretion ≥300 mg/24h.

Diabetic patients are suggested to control albumin excretion every year. Urinary albumin collection can also be timed (normal value <20 mg/min) or a random spot collection (normal value <30 μg/mg). Abnormal values correlate with nephropathy.

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