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Nephrotic Syndrome

Nephrotic Syndrome basics

What is Nephrotic Syndrome (NS)?

Nephrotic Syndrome (NS) is a nonspecific disorder defined by the following characteristics:

·Protein in the urine (>3.5 g/day)

·Hypo-albuminemia (decreased levels of the protein albumin in blood)

·Hyperlipidemia (an increased level of fats in blood)

·Swelling (edema)

Nephrotic Syndrome can be primary or secondary. The most common types of primary NS are the Minimal Change Disease (MCD) and FSGS. 75% of children and 20% of adults with NS have got MCD. A secondary form means that it is the result of another disease including cancer, HIV-infection or Diabetes.

Depending on the severity and the clinical course of the disease, Nephrotic Syndrome can have a significant impact on patients' daily life.

Causes of Nephrotic Syndrome (NS)

The kidneys are constituted by millions of small filtering units- glomeruli, which can filter our blood. In these filtering units, wastes and extra water are filtered and excreted into the urine, whereas the important substances are restrained in the blood.

Nephrotic Syndrome is an immune disease caused by massive immune complexes deposited in the mesangial area of the kidney due to undue immune reaction.

Human body has two sets of immune system called innate immune system and back-up system. Excessive immune response occurs when the innate system continues to send signals to stimulate the back-up system to work, or the back-up system loses self-control ability. In either case, the renal function cells are impaired, resulting in immune complex deposits in the kidneys.

If you have been diagnosed with Nephrotic Syndrome, we're here to help. Call us: +86-311-86954186 OR Email us: kidneyabc@hotmail.com(Monday through Sunday) to make an appointment.

In many cases, people who have Nephrotic Syndrome don't have any noticeable physical symptoms. When symptoms are present, they can include:

·Swelling of the tissues around the eyes (periorbital edema) and in the feet or ankles (peripheral edema). This is the most common early symptom of Nephrotic Syndrome in both children and adults.

·Hypoalbuminuria - low levels of the protein albumin in the blood

·Hypercholesterolaemia - high levels of cholesterol in the blood

Nephrotic Syndrome symptoms

·Foamy appearance of the urine (proteinuria)

·Weight gain

·Decreased urine output

·Less frequent urination

·Tiredness

·Increased susceptibility to infections

·Increased risk of thrombosis (formation of blood clots)

·Dry skin

·Swelling of the scrotum (scrotal edema), which may lead to a cord in the testicles to twist.

If you have some of the above signs and symptoms, see your doctor to discuss what might be causing them.

If you have been diagnosed with Nephrotic Syndrome, we're here to help. Call us: +86-311-86954186 OR Email us: kidneyabc@hotmail.com(Monday through Sunday) to make an appointment.

Nephrotic Syndrome treatment

Usually, the treatments for Nephrotic Syndrome involve treating underlying medical condition, control the symptoms or treat complications. Medications may include blood pressure medications, immune-system-suppressing medications, diuretics, cholesterol-reducing medications, blood thinners, etc.

Sometimes treatment for Nephrotic Syndrome is unsuccessful. If this occurs, patients may develop chronic kidney disease. The doctor may recommend that end-stage renal disease (ESRD) patients begin dialysis or consider a kidney transplant.

New holistic treatment for Nephrotic Syndrome-Immunotherapy

Nephrotic Syndrome belongs to an autoimmune defect disease. People affected by this disorder usually experience hematuria, urine protein, swelling, fatigue, hypertension, etc. These symptoms occur due to massive immune complexes deposited in mesangial area of the kidney.

Immunotherapy can help Nephrotic Syndrome patients remove these immune complexes, restrain the immune reaction and restore the immunity network. By this way, the disease can be treated from the root cause and it will never relapse again.

In order to prevent further kidney damage, series of immunosuppressants and immunosuppressive technology are used to rapidly block the immune reaction, so the inflammation injury to tissues and cells can be stopped. However, the injured inherent cells and immune complexes haven't been removed, so immune tolerance treatment is necessary to make the body be adaptable to this fact. Due to the repellency function, our body cannot co-exist with immune complex and impaired cells for a long time, so we must remove them.

Through promoting blood circulation and removing blood stasis, Chinese medicines are used to clear away the immune complex. In addition, Chinese prescriptions are also used to improve the immunity. Then the following immune protection treatment can protect the damaged and healthy renal intrinsic cells from being impaired again. At the same time, the renal cells and tissue can be restored. Finally, the immune clearance treatment can help us remove the immune complexes thoroughly.

If you have been diagnosed with Nephrotic Syndrome, we're here to help. Call us: +86-311-86954186 OR Email us: kidneyabc@hotmail.com(Monday through Sunday) to make an appointment.

Nephrotic Syndrome diagnosis

In addition to a physical examination and the assessment of family health history, other tests to diagnose Nephrotic Syndrome include:

·Urine tests. A urinalysis can reveal abnormalities in the urine, such as large amounts of protein (>3g/24h), if the person has NS. A 24-hour urine collection is needed for an accurate measure of the protein in the urine.

·Blood tests. If a person has Nephrotic Syndrome, a blood test may show low levels of the protein albumin specifically and, often, decreased levels of blood protein overall.

·Creatinine and creatinine clearance. Results of these tests give information on how well the kidneys are functioning.

·Kidney ultrasound to look at the kidneys. This exam helps to rule out other causes of the symptoms.

In adults, testing usually includes:

·Serum protein electrophoresis (SPEP)

·Antinuclear antibodies (ANA)

·Antibody tests for systemic lupus erythematosus

·C3 and C4 complement, proteins normally found in the blood

·Tests for hepatitis B, hepatitis C, and HIV

Unless Nephrotic Syndrome is clearly caused by Diabetes, a kidney biopsy may be recommended to remove a sample of kidney tissue for testing. Children do not usually have a biopsy.

If you have been diagnosed with Nephrotic Syndrome, we're here to help. Call us: +86-311-86954186 OR Email us: kidneyabc@hotmail.com(Monday through Sunday) to make an appointment.

Nephrotic Syndrome knowledge

Nephrotic Syndrome (NS) describes a condition in which the kidneys leak large and abnormal amounts of protein into the urine. When the protein is lost in the urine, this lead to puffiness or swelling (edema), often of the eyelids, feet and ankles, and eventually the abdomen.

▪ Marriage

Can people with Nephrotic Syndrome get married? This depends on patient's personal condition. For those who have been clinically improved after standard and effective treatment, they can establish a new family. This means that the existence of protein, red blood cells, white blood cells and cast in the urine all disappear, the kidney function recover to normal, and the disease don't recur two years after patients stop taking medicines.

While, patients with abnormal lab test index such as positive protein in urine are recommended to firstly adopt standard treatment. After the disease is clinically cured, they can consider getting married.

▪ Sexual Life

1. Avoid too frequent sexual activity. This is necessary for early and better recovery. Family member should positively cooperate with the treatment, which can reduce patient's psychological stress.

2. Pay attention to hygiene in sexual life so as to prevent infections which may aggravate the kidney damage.

3. During the treatment course, patients need to take contraception measures and avoid inducements like fatigue, cold or flu, etc. These factors may exacerbate the kidney disease.

▪ Pregnancy

Nephrotic Syndrome is a kind of chronic kidney disease which is difficult to treat. Pregnancy may exacerbate the renal disease. Both the mother and baby will face great risks of delayed development and premature. Hence, patients had better not get pregnant.

Certainly, not all of people with Nephrotic Syndrome cannot give birth to a children. Those who are in the following conditions can get pregnant:

1. The disease keeps stable for over two years, and series of lab tests are normal. Patients have no hematuria and the amount of protein in urine is less than 0.5g/day.

2. Kidney function is normal without relapse of kidney disease.

3. There are no high blood pressure, urinary tract infection and other complications.

If you have been diagnosed with Nephrotic Syndrome, we're here to help. Call us: +86-311-86954186 OR Email us: kidneyabc@hotmail.com(Monday through Sunday) to make an appointment.

Nephrotic Syndrome health care

Changes to your daily lifestyle may help you cope with Nephrotic Syndrome. The following give some useful suggestions. We hope that these tips can be helpful for all patients with the disease.

·Control the blood pressure well. The goal is to keep the level at or below 130/80mmHg. This is the most important measure to delay kidney damage.

·Modify daily diet arrangement. A low salt diet may help with swelling in the hands and legs. A moderate-protein diet (one gram of protein per kilogram of body weight per day) is also suggested. Choose lean sources of protein. Reduce the amount of fat and cholesterol in the diet to help control the blood cholesterol levels.

·Weight yourself each day to check for an increase in the weight, which may be a sign that you are retaining fluid. Call the doctor if you notice you are gaining weight or if you develop other problems.

·Practice good skin care to prevent additional skin problems like skin infections.

·Keep balance between work and rest

Avoid over-strain and strenuous exercise, both of which are factors that may result in aggravation of the disease. It is necessary to have enough rest and proper physical activities in the daily life.

·Not smoking or using other tobacco products, both of which are harmful to the recovery of kidney function.

·Take regular check-ups. Patients need to go for regular check-ups with the doctor. Even if they are well, it is very important that these regular visits occur because they help to monitor the patient's overall progress.

·Do regular sports and exercises. Patients can take part in all sports and activities that are within his or her capabilities. Ask the doctor if there are any questions about certain sports. Being active can also help prevent the patient from gaining too much weight.

If you have been diagnosed with Nephrotic Syndrome, we're here to help. Call us: +86-311-86954186 OR Email us: kidneyabc@hotmail.com(Monday through Sunday) to make an appointment.

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