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How Does Polycystic Kidney Disease (PKD) Cause Skin Itching

2013-08-31 16:44

How Does Polycystic Kidney Disease (PKD) Cause Skin ItchingIn most cases, people with Polycystic Kidney Disease (PKD) won’t suffer from skin itching until their condition develops to end stage. However, if itching appears, it isn’t a minor nuisance. The causes of skin itching due to PKD are various. Read on to find what causes your skin problem.

PKD is one condition that progresses chronically. In the early stage, all PKD renal cysts are small and under the capacity of kidneys, so no symptoms appear to remind of kidney damage. However, with the growth of these cysts, they will cause the decline of kidney function by replacing kidney normal tissues. Then, the following conditions may lead to skin itching.

High phosphorus level

Healthy kidneys are responsible for keeping calcium and phosphorus balance, but this balance is ruined easily in kidney disease as well as PKD. When calcium and phosphorus combine, they will form crystals that build up in the skin to irritate nerves and lead to itching.

The deposition of uremic toxins

Just as phosphorus build up, more and more uremic toxins will deposit in the body with the decline of kidney function. Then, some of them attack the nerve endings in the skin, resulting in tormenting itching.

High parathyroid hormone (PTH)

When the calcium level becomes low, parathyroid gland makes more PTH that can lead to the proliferation of certain cells in the skin. Finally, these cells release histamine, which is another reason of itchy skin.


Itching is one common complaint of people on dialysis. If you are undergoing dialysis, it may be the cause of your skin itching.

Since so many factors can lead to skin problem for people with Polycystic Kidney Disease, the treatment should depend on patients’ individual condition. Correct treatment can help you get rid of skin itching completely, while incorrect treatment may worsen your overall health. Working together with kidney experts here, you can find you indeed get more than you expect.

If you send us email, please leave your phone number or WhatsApp/Viber (with country code) in email so that our renal expert can communicate with you timely and directly. We will do utmost to help you solve the problems.

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