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What Are the Risk Factors of Purpura Nephritis

2012-11-22 11:49

Purpura nephritis is one of serious complications of Henoch-Schonlein purpura (HSP). However, not all patients with purpura will develop nephritis. Some studies reveal the following risk factor of purpura nephritis.

Your race

White and Asian children are more likely to develop purpura nephritis than black children.

Your gender

Some studies show that the risk of developing purpura nephritis among boys than that in girls.

Your age

The condition more commonly occurs among children and young adults, with the majority of cases happening in young children between 4 and 6 years of age.

Specific disease symptoms

Purpura not only involves kidneys, but also many other symptoms involving multiple organs like abdominal pain, severe bowel angina, persistent purpura, gastrointestinal bleeding etc. These symptoms can worsen the prognosis of purpura nephritis.


Frequent relapse is a significant risk factor in aggravating renal function in purpura nephritis. Every relapse can trigger the inflammation in kidneys, which can worsen renal function. Therefore, even if your ill keeps stable, you still should go to see a doctor and do regular monitoring.


Excessive protein in urine has toxic effects on kidney tissues and cells and can accelerate renal function deterioration. Therefore, it is very important to control proteinuria.

The above are the major risk factors of purpura nephritis, some of which are controllable, but some are not. To improve its prognosis, it is important to avoid the controllable factors like reducing proteinuria and relapses as well as controlling the relative complications.

As the controllable factors are due to purpura nephritis itself, the primary goal of the treatment should be treating the condition itself firstly. Immunotherapy is an alternative treatment for purpura nephritis. It aims at correcting the immune dysfunction and improving renal function by stimulating the restoring of the impaired kidney tissues and cells. This therapy can treat purpura nephritis from its underlying cause, it can prevent the disease from progressing into renal failure completely.

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