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Can Dialysis Cause Renal Amyloidosis


2012-09-12 17:51

Renal Amyloidosis contains two types. In the first type, primary Amyloidosis, the abnormal protein production occurs as a first step and lead to kidney disease. Dialysis-related Amyloidosis (DRA) is the result of kidney disease.

How does dialysis cause renal Amyloidosis?

In normal condition, kidneys remove extra small proteins and fluids from the blood, so as to keep blood levels normal. When kidneys are not functioned and develop the kidney failure, dialysis usually is used to replace the kidneys to work.

In patients with dialysis, a small sized protein called beta-2-microglobulin builds up in the blood. These proteins may join together, like the links of a chain, forming a few very large molecules from many smaller ones. These large molecules can form deposits and eventually damage the surrounding tissues and cause great discomfort.

This is how dialysis causes renal Amyloidosis.

Who is at risk to develop dialysis-related Amyloidosis?

Dialysis-related Amyloidosis often happens in patients, especially older adults, who have been on hemodialysis for over 5 years. For patients who are on hemodialysis, the hemodialysis membranes don’t effectively remove the large, complex beta-2-microglobulin proteins from the blood stream, because it has been used for many years. These molecules join together and form deposits and damage the surrounding tissues, causing symptoms.

How to deal with the renal Amyloidosis caused by dialysis?

The key is to use another blood detoxification to replace the dialysis and if the blood detoxification can eliminate beta-2-microglobulin, it will be perfect.

Blood purification is a systemic blood cleaning system, which offers various machines to deal with special type of waste products. It includes CRRT, hemoperfusion, hemofiltration, immune adsorption, plasma exchanges etc. Talk to your doctor and discuss which machine is proper for your condition.




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